Reaction Details Report a problem with these data
Target
Kappa-type opioid receptor
Ligand
BDBM50343626
Substrate
n/a
Meas. Tech.
ChEMBL_746703 (CHEMBL1776828)
Ki
0.140000±n/a nM
Citation
 Zhang, B; Zhang, T; Sromek, AW; Scrimale, T; Bidlack, JM; Neumeyer, JL Synthesis and binding affinity of novel mono- and bivalent morphinan ligands for κ, μ, and δ opioid receptors. Bioorg Med Chem 19:2808-16 (2011) [PubMed]  Article 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM50343626
Synonyms:
(5alpha)-17-Allyl-14-hydroxy-6-oxo-4,5-epoxymorphinan-3-yl-((-)-14-methoxyl-17-N-cyclobutylmethyl)morphinan-3-yl-decanedioate | CHEMBL1774948
Type:
Small organic molecule
Emp. Form.:
C51H66N2O8
Mol. Mass.:
835.0783
SMILES:
CO[C@@]12CCCC[C@@]11CCN(CC3CCC3)[C@@H]2Cc2ccc(OC(=O)CCCCCCCCC(=O)Oc3ccc4C[C@H]5N(CC=C)CC[C@@]67[C@@H](Oc3c46)C(=O)CC[C@@]57O)cc12 |r,TLB:11:10:18.60.17:2|
Structure:
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