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Target
Cytochrome c oxidase subunit 1
Ligand
BDBM50343721
Substrate
n/a
Meas. Tech.
ChEMBL_746069 (CHEMBL1775456)
IC50
130±n/a nM
Citation
 Wang, L; Hubert, JA; Lee, SJ; Pan, J; Qian, S; Reitman, ML; Strack, AM; Weingarth, DT; MacNeil, DJ; Weber, AE; Edmondson, SD Discovery of pyrimidine carboxamides as potent and selective CCK1 receptor agonists. Bioorg Med Chem Lett 21:2911-5 (2011) [PubMed]  Article 
Target
Name:
Cytochrome c oxidase subunit 1
Synonyms:
COI | COX1_HUMAN | COXI | MT-CO1 | MTCO1
Type:
PROTEIN
Mol. Mass.:
57042.74
Organism:
Homo sapiens (Human)
Description:
ChEMBL_746069
Residue:
513
Sequence:
MFADRWLFSTNHKDIGTLYLLFGAWAGVLGTALSLLIRAELGQPGNLLGNDHIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSLLLLLASAMVEAGAGTGWTVYPPLAGNYSHPGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAMTQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGSNMKWSAAVLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFIHWFPLFSGYTLDQTYAKIHFTIMFIGVNLTFFPQHFLGLSGMPRRYSDYPDAYTTWNILSSVGSFISLTAVMLMIFMIWEAFASKRKVLMVEEPSMNLEWLYGCPPPYHTFEEPVYMKS
  
Inhibitor
Name:
BDBM50343721
Synonyms:
3-(4-(4-(2-fluoro-4-methylphenyl)-5-(4-methoxyphenyl)pyrimidine-2-carbonyl)piperazin-1-yl)-1-naphthoic acid | CHEMBL1774043
Type:
Small organic molecule
Emp. Form.:
C34H29FN4O4
Mol. Mass.:
576.6169
SMILES:
COc1ccc(cc1)-c1cnc(nc1-c1ccc(C)cc1F)C(=O)N1CCN(CC1)c1cc(C(O)=O)c2ccccc2c1
Structure:
Search PDB for entries with ligand similarity: