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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50344430
Substrate
n/a
Meas. Tech.
ChEMBL_748646 (CHEMBL1780499)
Ki
158±n/a nM
Citation
 Rack, E; Fröhlich, R; Schepmann, D; Wünsch, B Design, synthesis and pharmacological evaluation of spirocyclics(1) receptor ligands with exocyclic amino moiety (increased distance 1). Bioorg Med Chem 19:3141-51 (2011) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50344430
Synonyms:
CHEMBL1779994 | cis-N-Benzyl-3-methoxy-3,4-dihydrospiro-[[2]benzopyran-1,1'-cyclohexan]-4'-amine
Type:
Small organic molecule
Emp. Form.:
C22H27NO2
Mol. Mass.:
337.4553
SMILES:
COC1Cc2ccccc2[C@]2(CC[C@@H](CC2)NCc2ccccc2)O1 |r,wU:10.26,13.17,(37.38,4.22,;36.04,3.45,;36.04,1.91,;37.37,1.13,;37.36,-.41,;38.68,-1.17,;38.68,-2.69,;37.35,-3.46,;36.04,-2.69,;36.04,-1.16,;34.7,-.4,;33.44,-.81,;31.8,-.19,;31.03,-1.54,;32.22,-1.12,;33.94,-1.74,;29.69,-.78,;29.68,.77,;28.35,1.54,;28.36,3.09,;27.02,3.86,;25.68,3.09,;25.69,1.53,;27.02,.77,;34.7,1.14,)|
Structure:
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