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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50344437
Substrate
n/a
Meas. Tech.
ChEMBL_748646 (CHEMBL1780499)
Ki
107±n/a nM
Citation
 Rack, E; Fröhlich, R; Schepmann, D; Wünsch, B Design, synthesis and pharmacological evaluation of spirocyclics(1) receptor ligands with exocyclic amino moiety (increased distance 1). Bioorg Med Chem 19:3141-51 (2011) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50344437
Synonyms:
CHEMBL1780001 | cis-N-Benzyl-N-ethyl-3-methoxy-3,4-dihydrospiro-[[2]benzopyran-1,1'-cyclohexan]-4'-amine
Type:
Small organic molecule
Emp. Form.:
C24H31NO2
Mol. Mass.:
365.5084
SMILES:
CCN(Cc1ccccc1)[C@H]1CC[C@]2(CC1)OC(Cc1ccccc21)OC |r,wU:10.10,13.17,(16.51,-23.15,;17.85,-23.92,;19.18,-23.15,;19.18,-21.61,;20.52,-20.83,;21.85,-21.61,;23.19,-20.83,;23.19,-19.29,;21.84,-18.52,;20.51,-19.29,;20.53,-23.92,;21.29,-22.56,;22.93,-23.19,;24.2,-22.77,;23.43,-24.12,;21.72,-23.5,;24.2,-21.24,;25.53,-20.47,;26.87,-21.24,;26.86,-22.78,;28.18,-23.54,;28.18,-25.06,;26.85,-25.84,;25.53,-25.06,;25.53,-23.54,;25.54,-18.92,;26.88,-18.16,)|
Structure:
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