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Target
Serine/threonine-protein kinase B-raf
Ligand
BDBM50344474
Substrate
n/a
Meas. Tech.
ChEMBL_747761 (CHEMBL1780960)
IC50
1516±n/a nM
Citation
 Newhouse, BJ; Hansen, JD; Grina, J; Welch, M; Topalov, G; Littman, N; Callejo, M; Martinson, M; Galbraith, S; Laird, ER; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Non-oxime pyrazole based inhibitors of B-Raf kinase. Bioorg Med Chem Lett 21:3488-92 (2011) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase B-raf
Synonyms:
B-RAF | B-Raf Protein Kinase | B-Raf proto-oncogene serine/threonine-protein kinase | BRAF | BRAF1 | BRAF_HUMAN | RAFB1 | p94 | v-Raf murine sarcoma viral oncogene homolog B1
Type:
Serine/threonine-protein kinase
Mol. Mass.:
84446.00
Organism:
Homo sapiens (Human)
Description:
P15056
Residue:
766
Sequence:
MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH
  
Inhibitor
Name:
BDBM50344474
Synonyms:
CHEMBL1780171 | cis-4-(4-(2,4-dihydroindeno[1,2-c]pyrazol-6-yl)-3-(pyridin-4-yl)-1H-pyrazol-1-yl)cyclohexanamine
Type:
Small organic molecule
Emp. Form.:
C24H24N6
Mol. Mass.:
396.4876
SMILES:
N[C@H]1CC[C@H](CC1)n1cc(c(n1)-c1ccncc1)-c1ccc-2c(Cc3c[nH]nc-23)c1 |r,wD:4.7,1.0,(30.59,1.1,;29.05,1.11,;28.29,2.45,;26.74,2.46,;25.98,1.13,;26.74,-.21,;28.27,-.22,;24.44,1.13,;23.54,2.37,;22.07,1.9,;22.07,.37,;23.54,-.12,;20.82,-.54,;19.49,.23,;18.16,-.54,;18.16,-2.09,;19.49,-2.86,;20.83,-2.09,;20.74,2.68,;20.76,4.21,;19.43,4.99,;18.09,4.22,;18.09,2.67,;16.62,2.19,;15.71,3.44,;14.24,3.91,;14.23,5.45,;15.69,5.94,;16.61,4.69,;19.42,1.91,)|
Structure:
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