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Target
MAP kinase-activated protein kinase 2
Ligand
BDBM50344749
Substrate
n/a
Meas. Tech.
ChEMBL_749131 (CHEMBL1780728)
EC50
28±n/a nM
Citation
 Barf, T; Kaptein, A; de Wilde, S; van der Heijden, R; van Someren, R; Demont, D; Schultz-Fademrecht, C; Versteegh, J; van Zeeland, M; Seegers, N; Kazemier, B; van de Kar, B; van Hoek, M; de Roos, J; Klop, H; Smeets, R; Hofstra, C; Hornberg, J; Oubrie, A Structure-based lead identification of ATP-competitive MK2 inhibitors. Bioorg Med Chem Lett 21:3818-22 (2011) [PubMed]  Article 
Target
Name:
MAP kinase-activated protein kinase 2
Synonyms:
MAP kinase-activated protein kinase 2 (MAPKAPK2) | MAP kinase-activated protein kinase 2 (MK2) | MAP kinase-activated protein kinase 2 (p38/MK2) | MAPK-Activated Protein Kinase 2 (MK2) | MAPK-activated protein kinase 2 | MAPK2_HUMAN | MAPKAP kinase 2 | MAPKAPK-2 | MAPKAPK2 | MK2
Type:
Serine/threonine-protein kinase
Mol. Mass.:
45579.87
Organism:
Homo sapiens (Human)
Description:
P49137
Residue:
400
Sequence:
MLSNSQGQSPPVPFPAPAPPPQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMTSALATMRVDYEQIKIKKIEDASNPLLLKRRKKARALEAAALAH
  
Inhibitor
Name:
BDBM50344749
Synonyms:
1-(2-aminoethyl)-3-(2-(quinolin-3-yl)pyridin-4-yl)-1H-pyrazole-5-carboxylic acid | 1-(2-aminoethyl)-3-[2-(quinolin-3-yl)pyridin-4-yl]-1H-pyrazole-5-carboxylic acid | CHEMBL1738780
Type:
Small organic molecule
Emp. Form.:
C20H17N5O2
Mol. Mass.:
359.3813
SMILES:
NCCn1nc(cc1C(O)=O)-c1ccnc(c1)-c1cnc2ccccc2c1
Structure:
Search PDB for entries with ligand similarity: