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Target
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Ligand
BDBM50346119
Substrate
n/a
Meas. Tech.
ChEMBL_750542 (CHEMBL1786303)
IC50
1500±n/a nM
Citation
 Naganuma, K; Omura, A; Maekawara, N; Saitoh, M; Ohkawa, N; Kubota, T; Nagumo, H; Kodama, T; Takemura, M; Ohtsuka, Y; Nakamura, J; Tsujita, R; Kawasaki, K; Yokoi, H; Kawanishi, M Discovery of selective PDE4B inhibitors. Bioorg Med Chem Lett 19:3174-6 (2009) [PubMed]  Article 
Target
Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Synonyms:
3',5'-cyclic phosphodiesterase | DPDE3 | PDE43 | PDE4D | PDE4D_HUMAN | Phosphodiesterase 4D
Type:
Protein
Mol. Mass.:
91092.69
Organism:
Homo sapiens (Human)
Description:
Q08499
Residue:
809
Sequence:
MEAEGSSAPARAGSGEGSDSAGGATLKAPKHLWRHEQHHQYPLRQPQFRLLHPHHHLPPPPPPSPQPQPQCPLQPPPPPPLPPPPPPPGAARGRYASSGATGRVRHRGYSDTERYLYCRAMDRTSYAVETGHRPGLKKSRMSWPSSFQGLRRFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVGEEEESQPEACVIDDRSPDT
  
Inhibitor
Name:
BDBM50346119
Synonyms:
2-(4-(5-ethyl-6-methyl-2-(5-(methylthio)thiophen-2-yl)pyrimidin-4-ylamino)phenyl)acetic acid | CHEMBL1782304
Type:
Small organic molecule
Emp. Form.:
C20H21N3O2S2
Mol. Mass.:
399.53
SMILES:
CCc1c(C)nc(nc1Nc1ccc(CC(O)=O)cc1)-c1ccc(SC)s1
Structure:
Search PDB for entries with ligand similarity: