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Target
Tyrosine-protein phosphatase non-receptor type 1
Ligand
BDBM50346150
Substrate
n/a
Meas. Tech.
ChEMBL_750565 (CHEMBL1786429)
IC50
1500±n/a nM
Citation
 Kumar, A; Maurya, RA; Sharma, S; Ahmad, P; Singh, AB; Tamrakar, AK; Srivastava, AK Design and synthesis of 3,5-diarylisoxazole derivatives as novel class of anti-hyperglycemic and lipid lowering agents. Bioorg Med Chem 17:5285-92 (2009) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 1
Synonyms:
PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B)
Type:
Protein phosphatase
Mol. Mass.:
49963.76
Organism:
Homo sapiens (Human)
Description:
Human recombinant GST-fusion PTP1B (1-435).
Residue:
435
Sequence:
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLTAGAYLCYRFLFNSNT
  
Inhibitor
Name:
BDBM50346150
Synonyms:
5-(2-(2-(1H-pyrrol-1-yl)ethoxy)-4-methoxyphenyl)-3-phenylisoxazole | CHEMBL1783776
Type:
Small organic molecule
Emp. Form.:
C22H24N2O3
Mol. Mass.:
364.4376
SMILES:
COc1ccc(-c2cc(no2)-c2ccccc2)c(OCCN2CCCC2)c1
Structure:
Search PDB for entries with ligand similarity: