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Target
Voltage-dependent calcium channel subunit alpha-2/delta-2
Ligand
BDBM50348473
Substrate
n/a
Meas. Tech.
ChEMBL_754900 (CHEMBL1805884)
IC50
794±n/a nM
Citation
 Myatt, JW; Healy, MP; Bravi, GS; Billinton, A; Johnson, CN; Matthews, KL; Jandu, KS; Meng, W; Hersey, A; Livermore, DG; Douault, CB; Witherington, J; Bit, RA; Rowedder, JE; Brown, JD; Clayton, NM Pyrazolopyridazine alpha-2-delta-1 ligands for the treatment of neuropathic pain. Bioorg Med Chem Lett 20:4683-8 (2010) [PubMed]  Article 
Target
Name:
Voltage-dependent calcium channel subunit alpha-2/delta-2
Synonyms:
CA2D2_HUMAN | CACNA2D2 | KIAA0558 | Voltage-gated calcium channel | Voltage-gated calcium channel alpha2/delta subunit 2
Type:
PROTEIN
Mol. Mass.:
129803.50
Organism:
Homo sapiens (Human)
Description:
ChEMBL_754900
Residue:
1150
Sequence:
MAVPARTCGASRPGPARTARPWPGCGPHPGPGTRRPTSGPPRPLWLLLPLLPLLAAPGASAYSFPQQHTMQHWARRLEQEVDGVMRIFGGVQQLREIYKDNRNLFEVQENEPQKLVEKVAGDIESLLDRKVQALKRLADAAENFQKAHRWQDNIKEEDIVYYDAKADAELDDPESEDVERGSKASTLRLDFIEDPNFKNKVNYSYAAVQIPTDIYKGSTVILNELNWTEALENVFMENRRQDPTLLWQVFGSATGVTRYYPATPWRAPKKIDLYDVRRRPWYIQGASSPKDMVIIVDVSGSVSGLTLKLMKTSVCEMLDTLSDDDYVNVASFNEKAQPVSCFTHLVQANVRNKKVFKEAVQGMVAKGTTGYKAGFEYAFDQLQNSNITRANCNKMIMMFTDGGEDRVQDVFEKYNWPNRTVRVFTFSVGQHNYDVTPLQWMACANKGYYFEIPSIGAIRINTQEYLDVLGRPMVLAGKEAKQVQWTNVYEDALGLGLVVTGTLPVFNLTQDGPGEKKNQLILGVMGIDVALNDIKRLTPNYTLGANGYVFAIDLNGYVLLHPNLKPQTTNFREPVTLDFLDAELEDENKEEIRRSMIDGNKGHKQIRTLVKSLDERYIDEVTRNYTWVPIRSTNYSLGLVLPPYSTFYLQANLSDQILQVKLPISKLKDFEFLLPSSFESEGHVFIAPREYCKDLNASDNNTEFLKNFIELMEKVTPDSKQCNNFLLHNLILDTGITQQLVERVWRDQDLNTYSLLAVFAATDGGITRVFPNKAAEDWTENPEPFNASFYRRSLDNHGYVFKPPHQDALLRPLELENDTVGILVSTAVELSLGRRTLRPAVVGVKLDLEAWAEKFKVLASNRTHQDQPQKCGPNSHCEMDCEVNNEDLLCVLIDDGGFLVLSNQNHQWDQVGRFFSEVDANLMLALYNNSFYTRKESYDYQAACAPQPPGNLGAAPRGVFVPTVADFLNLAWWTSAAAWSLFQQLLYGLIYHSWFQADPAEAEGSPETRESSCVMKQTQYYFGSVNASYNAIIDCGNCSRLFHAQRLTNTNLLFVVAEKPLCSQCEAGRLLQKETHSDGPEQCELVQRPRYRRGPHICFDYNATEDTSDCGRGASFPPSLGVLVSLQLLLLLGLPPRPQPQVLVHASRRL
  
Inhibitor
Name:
BDBM50348473
Synonyms:
CHEMBL1801185
Type:
Small organic molecule
Emp. Form.:
C18H17ClF3N5O
Mol. Mass.:
411.809
SMILES:
Cc1n(nc2c(nnc(C)c12)N1CCCC1)-c1ccc(Cl)cc1OC(F)(F)F
Structure:
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