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Target
Neuropeptide S receptor
Ligand
BDBM50348617
Substrate
n/a
Meas. Tech.
ChEMBL_755375 (CHEMBL1804531)
IC50
43±n/a nM
Citation
 Trotter, BW; Nanda, KK; Manley, PJ; Uebele, VN; Condra, CL; Gotter, AL; Menzel, K; Henault, M; Stocco, R; Renger, JJ; Hartman, GD; Bilodeau, MT Tricyclic imidazole antagonists of the Neuropeptide S Receptor. Bioorg Med Chem Lett 20:4704-8 (2010) [PubMed]  Article 
Target
Name:
Neuropeptide S receptor
Synonyms:
GPR154 | GPRA | NPSR1 | NPSR1_HUMAN | PGR14
Type:
PROTEIN
Mol. Mass.:
42692.30
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1276607
Residue:
371
Sequence:
MPANFTEGSFDSSGTGQTLDSSPVACTETVTFTEVVEGKEWGSFYYSFKTEQLITLWVLFVFTIVGNSVVLFSTWRRKKKSRMTFFVTQLAITDSFTGLVNILTDINWRFTGDFTAPDLVCRVVRYLQVVLLYASTYVLVSLSIDRYHAIVYPMKFLQGEKQARVLIVIAWSLSFLFSIPTLIIFGKRTLSNGEVQCWALWPDDSYWTPYMTIVAFLVYFIPLTIISIMYGIVIRTIWIKSKTYETVISNCSDGKLCSSYNRGLISKAKIKAIKYSIIIILAFICCWSPYFLFDILDNFNLLPDTQERFYASVIIQNLPALNSAINPLIYCVFSSSISFPCREQRSQDSRMTFRERTERHEMQILSKPEFI
  
Inhibitor
Name:
BDBM50348617
Synonyms:
CHEMBL1801361
Type:
Small organic molecule
Emp. Form.:
C24H26ClN3O2
Mol. Mass.:
423.935
SMILES:
CCN(CC)C(=O)CCC1(c2c(cccc2OC)-c2nccn12)c1ccc(Cl)cc1
Structure:
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