Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 6
Ligand
BDBM34141
Substrate
n/a
Meas. Tech.
ChEMBL_759558 (CHEMBL1811084)
Ki
2.1±n/a nM
Citation
 Nirogi, R; Dwarampudi, A; Kambhampati, R; Bhatta, V; Kota, L; Shinde, A; Badange, R; Jayarajan, P; Bhyrapuneni, G; Dubey, PK Rigidized 1-aryl sulfonyl tryptamines: synthesis and pharmacological evaluation as 5-HT6 receptor ligands. Bioorg Med Chem Lett 21:4577-80 (2011) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 6
Synonyms:
5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46968.43
Organism:
Homo sapiens (Human)
Description:
P50406
Residue:
440
Sequence:
MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN
  
Inhibitor
Name:
BDBM34141
Synonyms:
CHEMBL76237 | MS-245
Type:
Small organic molecule
Emp. Form.:
C19H22N2O3S
Mol. Mass.:
358.455
SMILES:
COc1ccc2n(cc(CCN(C)C)c2c1)S(=O)(=O)c1ccccc1
Structure:
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