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Target
Cytochrome P450 2D6
Ligand
BDBM50350389
Substrate
n/a
Meas. Tech.
ChEMBL_761210 (CHEMBL1816480)
IC50
6960±n/a nM
Citation
 Shao, L; Hewitt, MC; Malcolm, SC; Wang, F; Ma, J; Campbell, UC; Spicer, NA; Engel, SR; Hardy, LW; Jiang, ZD; Schreiber, R; Spear, KL; Varney, MA Synthesis and pharmacological characterization of bicyclic triple reuptake inhibitor 3-aryl octahydrocyclopenta[c]pyrrole analogues. J Med Chem 54:5283-95 (2011) [PubMed]  Article 
Target
Name:
Cytochrome P450 2D6
Synonyms:
CP2D6_HUMAN | CYP2D6 | CYP2DL1 | CYPIID6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1
Type:
Protein
Mol. Mass.:
55774.82
Organism:
Homo sapiens (Human)
Description:
P10635
Residue:
497
Sequence:
MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVPR
  
Inhibitor
Name:
BDBM50350389
Synonyms:
CHEMBL1813475
Type:
Small organic molecule
Emp. Form.:
C13H15Cl2N
Mol. Mass.:
256.171
SMILES:
Clc1ccc(cc1Cl)[C@@]12CCC[C@@H]1CNC2 |r|
Structure:
Search PDB for entries with ligand similarity: