Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 5
Ligand
BDBM50242053
Substrate
n/a
Meas. Tech.
ChEMBL_764122 (CHEMBL1821333)
IC50
5430±n/a nM
Citation
 Haney, KM; Zhang, F; Arnatt, CK; Yuan, Y; Li, G; Ware, JL; Gewirtz, DA; Zhang, Y The natural product CCR5 antagonist anibamine and its analogs as anti-prostate cancer agents. Bioorg Med Chem Lett 21:5159-63 (2011) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 5
Synonyms:
C-C CKR-5 | C-C chemokine receptor type 5 | CC-CKR-5 | CCR-5 | CCR5 | CCR5/mu opioid receptor complex | CCR5_HUMAN | CD_antigen=CD195 | CHEMR13 | CMKBR5 | HIV-1 fusion coreceptor
Type:
Enzyme
Mol. Mass.:
40540.21
Organism:
Homo sapiens (Human)
Description:
P51681
Residue:
352
Sequence:
MDYQVSSPIYDINYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKRLKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAVVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQKEGLHYTCSSHFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL
  
Inhibitor
Name:
BDBM50242053
Synonyms:
6,8-didec-(1Z)-enyl-5,7-dimethyl-2,3-dihydro-1H-indolizinium trifluoroacetic acid salt | Anibamine | CHEMBL2057533 | CHEMBL469649 | anibamine TFA
Type:
Small organic molecule
Emp. Form.:
C30H50N
Mol. Mass.:
424.7242
SMILES:
CCCCCCCC\C=C/c1c2CCC[n+]2c(C)c(\C=C/CCCCCCCC)c1C
Structure:
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