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Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50351388
Substrate
n/a
Meas. Tech.
ChEMBL_764455 (CHEMBL1821007)
IC50
49±n/a nM
Citation
 Saito, T; Obitsu, T; Kondo, T; Matsui, T; Nagao, Y; Kusumi, K; Matsumura, N; Ueno, S; Kishi, A; Katsumata, S; Kagamiishi, Y; Nakai, H; Toda, M 6,7-Dihydro-5H-cyclopenta[d]pyrazolo[1,5-a]pyrimidines and their derivatives as novel corticotropin-releasing factor 1 receptor antagonists. Bioorg Med Chem 19:5432-45 (2011) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50351388
Synonyms:
CHEMBL1819078
Type:
Small organic molecule
Emp. Form.:
C23H30N4OS
Mol. Mass.:
410.576
SMILES:
CCC(CC)Nc1c2CCCc2nc2c(c(C)nn12)-c1ccc(OC)cc1SC |(36.6,-14.42,;35.25,-15.17,;35.22,-16.71,;36.54,-17.5,;37.89,-16.76,;33.88,-17.45,;33.85,-18.99,;32.49,-19.74,;31.04,-19.23,;30.11,-20.47,;30.99,-21.73,;32.47,-21.28,;33.79,-22.08,;35.15,-21.32,;36.6,-21.81,;37.52,-20.58,;39.06,-20.6,;36.63,-19.33,;35.16,-19.78,;37.06,-23.28,;36.01,-24.41,;36.47,-25.88,;37.98,-26.22,;38.44,-27.69,;37.39,-28.82,;39.02,-25.08,;38.56,-23.61,;39.6,-22.48,;41.1,-22.81,)|
Structure:
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