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Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50351375
Substrate
n/a
Meas. Tech.
ChEMBL_764454 (CHEMBL1821006)
EC50
150±n/a nM
Citation
 Saito, T; Obitsu, T; Kondo, T; Matsui, T; Nagao, Y; Kusumi, K; Matsumura, N; Ueno, S; Kishi, A; Katsumata, S; Kagamiishi, Y; Nakai, H; Toda, M 6,7-Dihydro-5H-cyclopenta[d]pyrazolo[1,5-a]pyrimidines and their derivatives as novel corticotropin-releasing factor 1 receptor antagonists. Bioorg Med Chem 19:5432-45 (2011) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50351375
Synonyms:
CHEMBL1819065
Type:
Small organic molecule
Emp. Form.:
C22H28N4OS
Mol. Mass.:
396.549
SMILES:
CCC(CC)Nc1c2CSCc2nc2c(c(C)nn12)-c1ccc(OC)cc1C |(31.02,-13.82,;29.68,-14.56,;29.65,-16.1,;30.97,-16.9,;32.31,-16.15,;28.3,-16.85,;28.27,-18.39,;26.92,-19.13,;25.46,-18.63,;24.53,-19.86,;25.41,-21.12,;26.89,-20.67,;28.21,-21.47,;29.57,-20.71,;31.02,-21.21,;31.94,-19.97,;33.48,-19.99,;31.05,-18.72,;29.59,-19.18,;31.48,-22.68,;30.44,-23.8,;30.9,-25.27,;32.4,-25.61,;32.86,-27.08,;31.82,-28.22,;33.44,-24.47,;32.98,-23.01,;34.02,-21.87,)|
Structure:
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