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Target
Autoinducer 1 sensor kinase/phosphatase LuxN
Ligand
BDBM50351503
Substrate
n/a
Meas. Tech.
ChEMBL_765226 (CHEMBL1827779)
IC50
2700±n/a nM
Citation
 Lowery, CA; Salzameda, NT; Sawada, D; Kaufmann, GF; Janda, KD Medicinal chemistry as a conduit for the modulation of quorum sensing. J Med Chem 53:7467-89 (2010) [PubMed]  Article 
Target
Name:
Autoinducer 1 sensor kinase/phosphatase LuxN
Synonyms:
LUXN_VIBHA | luxN
Type:
PROTEIN
Mol. Mass.:
96099.26
Organism:
Vibrio harveyi
Description:
ChEMBL_765226
Residue:
849
Sequence:
MFDFSLEAIVYAKAISLLATVAVVMMWLFYYCYRLKQKNEVIFGTHHAAYIAYSVCIIAWISSNAYFHTDLLPELGASAGMFMAKFANLASFFAFAFAYYFSCQLAAEQRKGKVHRWQQGIFVSLTVYSLFINLRPGLTVEHVDIVGPSQFIIEFGPHTSYFFIGLVSFVVLTLVNLVAMRTNSSKLTLAKTNYMIAGILVFMLSTAVIHLGMTYFMGDFSLTWLPPALSISEMLFVGYALLTSRFYSVKYIAYLALSVLLVCAIFVLPLGAIFIPLTESNQWLIAIPICALIGITWQLLYKKTSRYASFLIYGDKKTPVQQILSLEEDFKLSIDDAMRRLGKLLQIPNDKLRLVTSNYNETFYEEYLSSNRSVLVFDELSEELEYKVSAKRSMKALYDKMSSNNTALVMPLFGQGKSVTHLLISPHKSNNQMFSNEEISAVQTLLTRVQSTIEADRRIRQSRALANSIAHEMRNPLAQVQLQFEALKQHIENHAPVEQITLDIENGQAAIQRGRQLIDIILREVSDSSPEHEPIAMTSIHKAVDQAVSHYGFENEKIIERIRLPQHTDFVAKLNETLFNFVIFNLIRNAIYYFDSYPDSQIEISTKTGPYENTLIFRDTGPGIDETISHKIFDDFFSYQKSGGSGLGLGYCQRVMRSFGGRIECKSKLGTFTEFHLYFPVVPNAPKADTLRTPYFNDWKQNKRSNEHKVAPNVQINNQSPTVLIVDDKEVQRALVQMYLNQLGVNSLQANNGENAVEVFKANHVDLILMDVQMPVMNGFDASQRIKELSPQTPIVALSGESGERELDMINKLMDGRLEKPTTLNALRHVLGNWLNKNTASSACEAERE
  
Inhibitor
Name:
BDBM50351503
Synonyms:
CHEMBL1823946
Type:
Small organic molecule
Emp. Form.:
C23H28ClN3O4S
Mol. Mass.:
478.004
SMILES:
CC(C)CC(NS(=O)(=O)c1ccc2CCN(C(C)=O)c2c1)C(=O)NCc1ccc(Cl)cc1
Structure:
Search PDB for entries with ligand similarity: