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Target
Cyclin-dependent kinase 2
Ligand
BDBM50352830
Substrate
n/a
Meas. Tech.
ChEMBL_767265 (CHEMBL1825377)
IC50
>25000±n/a nM
Citation
 Ashton, KS; St Jean, DJ; Poon, SF; Lee, MR; Allen, JG; Zhang, S; Lofgren, JA; Zhang, X; Fotsch, C; Hungate, R Design and synthesis of novel amide AKT1 inhibitors with selectivity over CDK2. Bioorg Med Chem Lett 21:5191-6 (2011) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 2
Synonyms:
CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Homo sapiens (Human)
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Inhibitor
Name:
BDBM50352830
Synonyms:
CHEMBL1823636
Type:
Small organic molecule
Emp. Form.:
C22H21F2N3O
Mol. Mass.:
381.4184
SMILES:
Fc1ccc(cc1F)C(NC(=O)c1ccc2cnccc2c1)C1CCNCC1
Structure:
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