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Target
Renin
Ligand
BDBM50352897
Substrate
n/a
Meas. Tech.
ChEMBL_767618 (CHEMBL1825730)
IC50
4090±n/a nM
Citation
 Matter, H; Scheiper, B; Steinhagen, H; Böcskei, Z; Fleury, V; McCort, G Structure-based design and optimization of potent renin inhibitors on 5- or 7-azaindole-scaffolds. Bioorg Med Chem Lett 21:5487-92 (2011) [PubMed]  Article 
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
  
Inhibitor
Name:
BDBM50352897
Synonyms:
CHEMBL1824901
Type:
Small organic molecule
Emp. Form.:
C29H37FN4O3
Mol. Mass.:
508.6275
SMILES:
COC[C@H]1CN(CCN1)C(=O)c1c(Cc2cccc(F)c2C)n(C2CCCCC2)c2cc(OC)ncc12 |r|
Structure:
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