Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 5
Ligand
BDBM50353140
Substrate
n/a
Meas. Tech.
ChEMBL_768586 (CHEMBL1832605)
Ki
200±n/a nM
Citation
 Wu, L; Lu, K; Desai, M; Packiarajan, M; Joshi, A; Marzabadi, MR; Jubian, V; Andersen, K; Chandrasena, G; Boyle, NJ; Walker, MW N-Heteroaryl glycinamides and glycinamines as potent NPY5 antagonists. Bioorg Med Chem Lett 21:5573-6 (2011) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 5
Synonyms:
NPY-Y5 | NPY-Y5 receptor | NPY5-R | NPY5R | NPY5R_HUMAN | NPYR5 | NPYY5 | Neuropeptide Y receptor type 5 | Neuropeptide Y receptor type 5 ( NPY Y5) | Y5 receptor
Type:
Enzyme
Mol. Mass.:
50746.64
Organism:
Homo sapiens (Human)
Description:
Q15761
Residue:
445
Sequence:
MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
  
Inhibitor
Name:
BDBM50353140
Synonyms:
CHEMBL1829312
Type:
Small organic molecule
Emp. Form.:
C22H33N3O4S2
Mol. Mass.:
467.645
SMILES:
CCS(=O)(=O)NC[C@H]1CC[C@@H](CC1)NC(=O)CN1c2ccccc2SC(C)(C)CC1=O |r,wU:10.13,wD:7.6,(34.12,-10.51,;32.78,-9.77,;31.46,-10.57,;30.68,-11.89,;32.22,-11.89,;30.11,-9.82,;28.79,-10.62,;27.44,-9.88,;27.41,-8.34,;26.06,-7.6,;24.75,-8.4,;24.78,-9.94,;26.13,-10.68,;23.4,-7.67,;22.09,-8.47,;22.13,-10.01,;20.73,-7.74,;19.42,-8.54,;18.23,-7.53,;18.74,-6.08,;17.74,-4.91,;16.22,-5.19,;15.7,-6.64,;16.71,-7.82,;15.98,-9.21,;16.62,-10.64,;16.61,-12.17,;15.28,-11.39,;18.13,-11.02,;19.38,-10.09,;20.75,-10.8,)|
Structure:
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