Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 5
Ligand
BDBM50353142
Substrate
n/a
Meas. Tech.
ChEMBL_768586 (CHEMBL1832605)
Ki
19±n/a nM
Citation
 Wu, L; Lu, K; Desai, M; Packiarajan, M; Joshi, A; Marzabadi, MR; Jubian, V; Andersen, K; Chandrasena, G; Boyle, NJ; Walker, MW N-Heteroaryl glycinamides and glycinamines as potent NPY5 antagonists. Bioorg Med Chem Lett 21:5573-6 (2011) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 5
Synonyms:
NPY-Y5 | NPY-Y5 receptor | NPY5-R | NPY5R | NPY5R_HUMAN | NPYR5 | NPYY5 | Neuropeptide Y receptor type 5 | Neuropeptide Y receptor type 5 ( NPY Y5) | Y5 receptor
Type:
Enzyme
Mol. Mass.:
50746.64
Organism:
Homo sapiens (Human)
Description:
Q15761
Residue:
445
Sequence:
MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
  
Inhibitor
Name:
BDBM50353142
Synonyms:
CHEMBL1829314
Type:
Small organic molecule
Emp. Form.:
C23H35N3O4S2
Mol. Mass.:
481.672
SMILES:
CC(C)S(=O)(=O)NC[C@H]1CC[C@@H](CC1)NC(=O)CN1c2ccccc2SC(C)(C)CC1=O |r,wU:11.14,wD:8.7,(30.6,-20.93,;29.25,-20.19,;29.21,-18.65,;27.93,-20.99,;27.15,-22.31,;28.69,-22.31,;26.58,-20.25,;25.26,-21.05,;23.91,-20.31,;23.88,-18.77,;22.53,-18.02,;21.22,-18.83,;21.25,-20.37,;22.6,-21.1,;19.87,-18.09,;18.56,-18.9,;18.6,-20.44,;17.2,-18.16,;15.89,-18.96,;14.7,-17.95,;15.21,-16.5,;14.21,-15.34,;12.69,-15.62,;12.17,-17.07,;13.18,-18.25,;12.45,-19.63,;13.09,-21.06,;13.08,-22.59,;11.75,-21.82,;14.6,-21.45,;15.85,-20.52,;17.22,-21.23,)|
Structure:
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