Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 5
Ligand
BDBM50353144
Substrate
n/a
Meas. Tech.
ChEMBL_768586 (CHEMBL1832605)
Ki
23±n/a nM
Citation
 Wu, L; Lu, K; Desai, M; Packiarajan, M; Joshi, A; Marzabadi, MR; Jubian, V; Andersen, K; Chandrasena, G; Boyle, NJ; Walker, MW N-Heteroaryl glycinamides and glycinamines as potent NPY5 antagonists. Bioorg Med Chem Lett 21:5573-6 (2011) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 5
Synonyms:
NPY-Y5 | NPY-Y5 receptor | NPY5-R | NPY5R | NPY5R_HUMAN | NPYR5 | NPYY5 | Neuropeptide Y receptor type 5 | Neuropeptide Y receptor type 5 ( NPY Y5) | Y5 receptor
Type:
Enzyme
Mol. Mass.:
50746.64
Organism:
Homo sapiens (Human)
Description:
Q15761
Residue:
445
Sequence:
MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
  
Inhibitor
Name:
BDBM50353144
Synonyms:
CHEMBL1829316
Type:
Small organic molecule
Emp. Form.:
C23H37N3O5S2
Mol. Mass.:
499.687
SMILES:
CC(C)S(=O)(=O)NC[C@H]1CC[C@@H](CC1)NC(=O)CN1CCC(C)(C)S(=O)(=O)c2ccccc12 |r,wU:11.14,wD:8.7,(34.12,-30.75,;32.77,-30.01,;32.73,-28.47,;31.45,-30.81,;30.67,-32.13,;32.21,-32.13,;30.1,-30.07,;28.79,-30.87,;27.44,-30.13,;27.4,-28.59,;26.05,-27.84,;24.74,-28.65,;24.77,-30.19,;26.12,-30.92,;23.39,-27.91,;22.08,-28.72,;22.12,-30.25,;20.73,-27.98,;19.41,-28.78,;19.37,-30.34,;18.12,-31.27,;16.61,-30.88,;16.6,-32.41,;15.27,-31.63,;15.98,-29.45,;14.87,-30.54,;14.63,-28.68,;16.7,-28.07,;15.7,-26.89,;16.21,-25.44,;17.73,-25.16,;18.73,-26.32,;18.22,-27.77,)|
Structure:
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