Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 5
Ligand
BDBM50353155
Substrate
n/a
Meas. Tech.
ChEMBL_768586 (CHEMBL1832605)
Ki
170±n/a nM
Citation
 Wu, L; Lu, K; Desai, M; Packiarajan, M; Joshi, A; Marzabadi, MR; Jubian, V; Andersen, K; Chandrasena, G; Boyle, NJ; Walker, MW N-Heteroaryl glycinamides and glycinamines as potent NPY5 antagonists. Bioorg Med Chem Lett 21:5573-6 (2011) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 5
Synonyms:
NPY-Y5 | NPY-Y5 receptor | NPY5-R | NPY5R | NPY5R_HUMAN | NPYR5 | NPYY5 | Neuropeptide Y receptor type 5 | Neuropeptide Y receptor type 5 ( NPY Y5) | Y5 receptor
Type:
Enzyme
Mol. Mass.:
50746.64
Organism:
Homo sapiens (Human)
Description:
Q15761
Residue:
445
Sequence:
MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
  
Inhibitor
Name:
BDBM50353155
Synonyms:
CHEMBL1829327
Type:
Small organic molecule
Emp. Form.:
C20H32FN3O3S
Mol. Mass.:
413.55
SMILES:
CC(C)S(=O)(=O)NC[C@H]1CC[C@@H](CC1)NCCN1CCOc2ccc(F)cc12 |r,wU:8.7,wD:11.14,(9.66,-34.35,;8.32,-33.57,;8.33,-32.03,;6.99,-34.34,;6.21,-35.67,;7.75,-35.67,;5.65,-33.56,;4.32,-34.34,;2.98,-33.56,;1.65,-34.33,;.32,-33.56,;.33,-32.02,;1.65,-31.24,;2.98,-32.02,;-1.01,-31.25,;-2.34,-32.02,;-3.68,-31.26,;-5.01,-32.02,;-5.02,-33.57,;-6.35,-34.34,;-7.68,-33.56,;-7.68,-32.03,;-9.01,-31.27,;-9.01,-29.72,;-7.69,-28.95,;-7.69,-27.41,;-6.35,-29.72,;-6.35,-31.27,)|
Structure:
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