Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 5
Ligand
BDBM50353156
Substrate
n/a
Meas. Tech.
ChEMBL_768586 (CHEMBL1832605)
Ki
110±n/a nM
Citation
 Wu, L; Lu, K; Desai, M; Packiarajan, M; Joshi, A; Marzabadi, MR; Jubian, V; Andersen, K; Chandrasena, G; Boyle, NJ; Walker, MW N-Heteroaryl glycinamides and glycinamines as potent NPY5 antagonists. Bioorg Med Chem Lett 21:5573-6 (2011) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 5
Synonyms:
NPY-Y5 | NPY-Y5 receptor | NPY5-R | NPY5R | NPY5R_HUMAN | NPYR5 | NPYY5 | Neuropeptide Y receptor type 5 | Neuropeptide Y receptor type 5 ( NPY Y5) | Y5 receptor
Type:
Enzyme
Mol. Mass.:
50746.64
Organism:
Homo sapiens (Human)
Description:
Q15761
Residue:
445
Sequence:
MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
  
Inhibitor
Name:
BDBM50353156
Synonyms:
CHEMBL1829328
Type:
Small organic molecule
Emp. Form.:
C20H31F2N3O3S
Mol. Mass.:
431.54
SMILES:
CC(C)S(=O)(=O)NC[C@H]1CC[C@@H](CC1)NCCN1CCOc2cc(F)c(F)cc12 |r,wU:8.7,wD:11.14,(32.07,-34.92,;30.74,-34.14,;30.74,-32.6,;29.4,-34.91,;28.62,-36.23,;30.16,-36.23,;28.08,-34.13,;26.74,-34.9,;25.41,-34.13,;24.07,-34.89,;22.74,-34.12,;22.75,-32.59,;24.07,-31.81,;25.41,-32.59,;21.41,-31.82,;20.08,-32.59,;18.74,-31.83,;17.42,-32.59,;17.42,-34.13,;16.08,-34.91,;14.75,-34.13,;14.75,-32.6,;13.41,-31.84,;13.42,-30.29,;12.08,-29.52,;14.74,-29.52,;14.74,-27.98,;16.08,-30.29,;16.09,-31.84,)|
Structure:
Search PDB for entries with ligand similarity: