Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 5
Ligand
BDBM50353160
Substrate
n/a
Meas. Tech.
ChEMBL_768586 (CHEMBL1832605)
Ki
9.2±n/a nM
Citation
 Wu, L; Lu, K; Desai, M; Packiarajan, M; Joshi, A; Marzabadi, MR; Jubian, V; Andersen, K; Chandrasena, G; Boyle, NJ; Walker, MW N-Heteroaryl glycinamides and glycinamines as potent NPY5 antagonists. Bioorg Med Chem Lett 21:5573-6 (2011) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 5
Synonyms:
NPY-Y5 | NPY-Y5 receptor | NPY5-R | NPY5R | NPY5R_HUMAN | NPYR5 | NPYY5 | Neuropeptide Y receptor type 5 | Neuropeptide Y receptor type 5 ( NPY Y5) | Y5 receptor
Type:
Enzyme
Mol. Mass.:
50746.64
Organism:
Homo sapiens (Human)
Description:
Q15761
Residue:
445
Sequence:
MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
  
Inhibitor
Name:
BDBM50353160
Synonyms:
CHEMBL1829332
Type:
Small organic molecule
Emp. Form.:
C21H32F3N3O3S
Mol. Mass.:
463.557
SMILES:
CC(C)S(=O)(=O)NC[C@H]1CC[C@@H](CC1)NCCN1CCOc2cc(ccc12)C(F)(F)F |r,wU:8.7,wD:11.14,(32.37,-.82,;31.04,-.05,;31.04,1.49,;29.7,-.81,;28.92,-2.14,;30.46,-2.14,;28.37,-.04,;27.03,-.81,;25.7,-.04,;24.36,-.8,;23.04,-.03,;23.04,1.51,;24.37,2.28,;25.7,1.51,;21.7,2.28,;20.37,1.5,;19.04,2.27,;17.7,1.5,;17.7,-.04,;16.37,-.81,;15.04,-.04,;15.04,1.49,;13.7,2.26,;13.7,3.8,;15.03,4.57,;16.37,3.81,;16.37,2.26,;12.37,4.57,;12.37,6.11,;11.03,3.8,;11.03,5.34,)|
Structure:
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