Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 5
Ligand
BDBM50353161
Substrate
n/a
Meas. Tech.
ChEMBL_768586 (CHEMBL1832605)
Ki
370±n/a nM
Citation
 Wu, L; Lu, K; Desai, M; Packiarajan, M; Joshi, A; Marzabadi, MR; Jubian, V; Andersen, K; Chandrasena, G; Boyle, NJ; Walker, MW N-Heteroaryl glycinamides and glycinamines as potent NPY5 antagonists. Bioorg Med Chem Lett 21:5573-6 (2011) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 5
Synonyms:
NPY-Y5 | NPY-Y5 receptor | NPY5-R | NPY5R | NPY5R_HUMAN | NPYR5 | NPYY5 | Neuropeptide Y receptor type 5 | Neuropeptide Y receptor type 5 ( NPY Y5) | Y5 receptor
Type:
Enzyme
Mol. Mass.:
50746.64
Organism:
Homo sapiens (Human)
Description:
Q15761
Residue:
445
Sequence:
MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
  
Inhibitor
Name:
BDBM50353161
Synonyms:
CHEMBL1829333
Type:
Small organic molecule
Emp. Form.:
C20H32ClN3O2S2
Mol. Mass.:
446.07
SMILES:
CC(C)S(=O)(=O)NC[C@H]1CC[C@@H](CC1)NCCN1CCSc2cc(Cl)ccc12 |r,wU:8.7,wD:11.14,(10.64,-8.81,;9.31,-8.04,;9.32,-6.5,;7.98,-8.8,;7.19,-10.13,;8.73,-10.13,;6.64,-8.03,;5.31,-8.8,;3.98,-8.02,;2.64,-8.79,;1.31,-8.02,;1.32,-6.48,;2.64,-5.7,;3.98,-6.48,;-.02,-5.71,;-1.35,-6.48,;-2.69,-5.72,;-4.02,-6.49,;-4.02,-8.03,;-5.35,-8.8,;-6.68,-8.03,;-6.68,-6.5,;-8.02,-5.73,;-8.02,-4.18,;-9.36,-3.41,;-6.69,-3.41,;-5.36,-4.18,;-5.35,-5.73,)|
Structure:
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