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Target
Carbonic anhydrase 12
Ligand
BDBM50278844
Substrate
n/a
Meas. Tech.
ChEMBL_770798 (CHEMBL1837603)
Ki
9.5±n/a nM
Citation
 Morris, JC; Chiche, J; Grellier, C; Lopez, M; Bornaghi, LF; Maresca, A; Supuran, CT; Pouysségur, J; Poulsen, SA Targeting hypoxic tumor cell viability with carbohydrate-based carbonic anhydrase IX and XII inhibitors. J Med Chem 54:6905-18 (2011) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 12
Synonyms:
CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3
Type:
Enzyme
Mol. Mass.:
39456.00
Organism:
Homo sapiens (Human)
Description:
Catalytic domain of human cloned isozyme was used in the assay
Residue:
354
Sequence:
MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGLSLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
  
Inhibitor
Name:
BDBM50278844
Synonyms:
4-(4-{[beta-D-glucopyranosyl]thiomethyl}-1-H-1,2,3-triazol-1-yl)benzenesulfonamide | CHEMBL498750
Type:
Small organic molecule
Emp. Form.:
C15H20N4O7S2
Mol. Mass.:
432.472
SMILES:
NS(=O)(=O)c1ccc(cc1)-n1cc(CS[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)nn1 |r|
Structure:
Search PDB for entries with ligand similarity: