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Target
Kappa-type opioid receptor
Ligand
BDBM50355118
Substrate
n/a
Meas. Tech.
ChEMBL_772292 (CHEMBL1838614)
Ki
>10000±n/a nM
Citation
 Liu, J; Yu, LF; Eaton, JB; Caldarone, B; Cavino, K; Ruiz, C; Terry, M; Fedolak, A; Wang, D; Ghavami, A; Lowe, DA; Brunner, D; Lukas, RJ; Kozikowski, AP Discovery of isoxazole analogues of sazetidine-A as selectivea4ß2-nicotinic acetylcholine receptor partial agonists for the treatment of depression. J Med Chem 54:7280-8 (2011) [PubMed]  Article 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM50355118
Synonyms:
CHEMBL1835609
Type:
Small organic molecule
Emp. Form.:
C15H19N3O3
Mol. Mass.:
289.3297
SMILES:
OCCCc1cc(on1)-c1cncc(OC[C@@H]2CCN2)c1 |r|
Structure:
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