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Target
Histone deacetylase 8
Ligand
BDBM50355335
Substrate
n/a
Meas. Tech.
ChEMBL_773032 (CHEMBL1838458)
IC50
960±n/a nM
Citation
 Zhang, Y; Feng, J; Jia, Y; Xu, Y; Liu, C; Fang, H; Xu, W Design, synthesis and primary activity assay of tripeptidomimetics as histone deacetylase inhibitors with linear linker and branched cap group. Eur J Med Chem 46:5387-97 (2011) [PubMed]  Article 
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM50355335
Synonyms:
CHEMBL1833988
Type:
Small organic molecule
Emp. Form.:
C22H38N4O6S2
Mol. Mass.:
518.69
SMILES:
CC(C)(C)OC(=O)NCCCC(=O)N1CC2(C[C@H]1C(=O)NCCCCCC(=O)NO)SCCS2 |r|
Structure:
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