Reaction Details Report a problem with these data
Target
Receptor-type tyrosine-protein kinase FLT3
Ligand
BDBM50355492
Substrate
n/a
Meas. Tech.
ChEMBL_773456 (CHEMBL1840408)
Ki
5±n/a nM
Citation
 Davies, RJ; Pierce, AC; Forster, C; Grey, R; Xu, J; Arnost, M; Choquette, D; Galullo, V; Tian, SK; Henkel, G; Chen, G; Heidary, DK; Ma, J; Stuver-Moody, C; Namchuk, M Design, synthesis, and evaluation of a novel dual FMS-like tyrosine kinase 3/stem cell factor receptor (FLT3/c-KIT) inhibitor for the treatment of acute myelogenous leukemia. J Med Chem 54:7184-92 (2011) [PubMed]  Article 
Target
Name:
Receptor-type tyrosine-protein kinase FLT3
Synonyms:
CD135 | CD_antigen: CD135 | FL cytokine receptor | FLK-2 | FLK2 | FLT-3 | FLT3 | FLT3_HUMAN | Fetal liver kinase-2 | Fms-like tyrosine kinase 3 | Fms-like tyrosine kinase 3 (Flt-3) | Fms-related tyrosine kinase 3 | STK-1 | STK1 | Stem cell tyrosine kinase 1
Type:
Enzyme
Mol. Mass.:
112888.62
Organism:
Homo sapiens (Human)
Description:
P36888
Residue:
993
Sequence:
MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS
  
Inhibitor
Name:
BDBM50355492
Synonyms:
CHEMBL1835871
Type:
Small organic molecule
Emp. Form.:
C23H29N7O
Mol. Mass.:
419.5227
SMILES:
Nc1nc(Nc2ccc(cc2)[C@@H]2CC[C@@H](CC2)N2CCOCC2)nn1-c1ccccn1 |r,wU:11.11,14.18,(2.59,-31.18,;4.06,-30.71,;4.55,-29.26,;6.09,-29.27,;6.84,-27.92,;8.38,-27.91,;9.16,-29.23,;10.7,-29.21,;11.46,-27.87,;10.67,-26.54,;9.13,-26.56,;13,-27.85,;13.78,-29.18,;15.32,-29.16,;16.08,-27.82,;15.29,-26.49,;13.75,-26.5,;17.62,-27.8,;18.4,-29.13,;19.93,-29.12,;20.7,-27.78,;19.92,-26.45,;18.37,-26.46,;6.55,-30.74,;5.3,-31.63,;5.28,-33.17,;6.6,-33.94,;6.59,-35.48,;5.25,-36.25,;3.92,-35.46,;3.93,-33.92,)|
Structure:
Search PDB for entries with ligand similarity: