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Target
Atypical kinase COQ8A, mitochondrial
Ligand
BDBM25919
Substrate
n/a
Meas. Tech.
ChEMBL_774596 (CHEMBL1908813)
Kd
>10000±n/a nM
Citation
 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol 29:1046-51 (2011) [PubMed]  Article 
Target
Name:
Atypical kinase COQ8A, mitochondrial
Synonyms:
ADCK3 | CABC1 | COQ8A | COQ8A_HUMAN | Chaperone activity of bc1 complex-like, mitochondrial
Type:
PROTEIN
Mol. Mass.:
71954.89
Organism:
Homo sapiens (Human)
Description:
ChEMBL_655673
Residue:
647
Sequence:
MAAILGDTIMVAKGLVKLTQAAVETHLQHLGIGGELIMAARALQSTAVEQIGMFLGKVQGQDKHEEYFAENFGGPEGEFHFSVPHAAGASTDFSSASAPDQSAPPSLGHAHSEGPAPAYVASGPFREAGFPGQASSPLGRANGRLFANPRDSFSAMGFQRRFFHQDQSPVGGLTAEDIEKARQAKARPENKQHKQTLSEHARERKVPVTRIGRLANFGGLAVGLGFGALAEVAKKSLRSEDPSGKKAVLGSSPFLSEANAERIVRTLCKVRGAALKLGQMLSIQDDAFINPHLAKIFERVRQSADFMPLKQMMKTLNNDLGPNWRDKLEYFEERPFAAASIGQVHLARMKGGREVAMKIQYPGVAQSINSDVNNLMAVLNMSNMLPEGLFPEHLIDVLRRELALECDYQREAACARKFRDLLKGHPFFYVPEIVDELCSPHVLTTELVSGFPLDQAEGLSQEIRNEICYNILVLCLRELFEFHFMQTDPNWSNFFYDPQQHKVALLDFGATREYDRSFTDLYIQIIRAAADRDRETVRAKSIEMKFLTGYEVKVMEDAHLDAILILGEAFASDEPFDFGTQSTTEKIHNLIPVMLRHRLVPPPEETYSLHRKMGGSFLICSKLKARFPCKAMFEEAYSNYCKRQAQQ
  
Inhibitor
Name:
BDBM25919
Synonyms:
BMS-345541 | BMS345541 | CHEMBL471496 | N-(2-aminoethyl)-3,12-dimethyl-2,5,8-triazatricyclo[7.4.0.0^{2,6}]trideca-1(13),3,5,7,9,11-hexaen-7-amine
Type:
Small organic molecule
Emp. Form.:
C14H17N5
Mol. Mass.:
255.3183
SMILES:
Cc1cnc2c(NCCN)nc3ccc(C)cc3n12
Structure:
Search PDB for entries with ligand similarity: