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Target
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma
Ligand
BDBM36409
Substrate
n/a
Meas. Tech.
ChEMBL_774614 (CHEMBL1908831)
Kd
780±n/a nM
Citation
 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol 29:1046-51 (2011) [PubMed]  Article 
Target
Name:
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma
Synonyms:
PI(5)P 4-kinase type II gamma | PI42C_HUMAN | PIP4K2C | PIP4KII-gamma | PIP5K2C | Phosphatidylinositol-5-phosphate 4-kinase type II gamma | Phosphatidylinositol-5-phosphate 4-kinase type-2 gamma
Type:
PROTEIN
Mol. Mass.:
47302.35
Organism:
Homo sapiens (Human)
Description:
ChEMBL_774614
Residue:
421
Sequence:
MASSSVPPATVSAATAGPGPGFGFASKTKKKHFVQQKVKVFRAADPLVGVFLWGVAHSINELSQVPPPVMLLPDDFKASSKIKVNNHLFHRENLPSHFKFKEYCPQVFRNLRDRFGIDDQDYLVSLTRNPPSESEGSDGRFLISYDRTLVIKEVSSEDIADMHSNLSNYHQYIVKCHGNTLLPQFLGMYRVSVDNEDSYMLVMRNMFSHRLPVHRKYDLKGSLVSREASDKEKVKELPTLKDMDFLNKNQKVYIGEEEKKIFLEKLKRDVEFLVQLKIMDYSLLLGIHDIIRGSEPEEEAPVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGYIHSHRPLGPGEFESFIDVYAIRSAEGAPQKEVYFMGLIDILTQYDAKKKAAHAAKTVKHGAGAEISTVHPEQYAKRFLDFITNIFA
  
Inhibitor
Name:
BDBM36409
Synonyms:
2-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1H-indol-5-ol, PP242 | CID24905147 | US10172858, Table 2.1 | US9828378, # 1
Type:
Small organic molecule
Emp. Form.:
C16H16N6O
Mol. Mass.:
308.3378
SMILES:
CC(C)n1nc(-c2cc3cc(O)ccc3[nH]2)c2c(N)ncnc12
Structure:
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