Reaction Details Report a problem with these data
Target
Interleukin-1 beta
Ligand
BDBM50355789
Substrate
n/a
Meas. Tech.
ChEMBL_776544 (CHEMBL1913641)
IC50
2700±n/a nM
Citation
 Stierle, DB; Stierle, AA; Patacini, B; McIntyre, K; Girtsman, T; Bolstad, E Berkeleyones and related meroterpenes from a deep water acid mine waste fungus that inhibit the production of interleukin 1-ß from induced inflammasomes. J Nat Prod 74:2273-7 (2011) [PubMed]  Article 
Target
Name:
Interleukin-1 beta
Synonyms:
IL1B | IL1B_HUMAN | IL1F2 | Interleukin 1-beta | Interleukin-1 beta | hIL-1beta
Type:
Cytokine
Mol. Mass.:
30734.47
Organism:
Homo sapiens (Human)
Description:
P01584
Residue:
269
Sequence:
MAEVPELASEMMAYYSGNEDDLFFEADGPKQMKCSFQDLDLCPLDGGIQLRISDHHYSKGFRQAASVVVAMDKLRKMLVPCPQTFQENDLSTFFPFIFEEEPIFFDTWDNEAYVHDAPVRSLNCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKEKNLYLSCVLKDDKPTLQLESVDPKNYPKKKMEKRFVFNKIEINNKLEFESAQFPNWYISTSQAENMPVFLGGTKGGQDITDFTMQFVSS
  
Inhibitor
Name:
BDBM50355789
Synonyms:
CHEMBL1911627
Type:
Small organic molecule
Emp. Form.:
C26H38O6
Mol. Mass.:
446.5763
SMILES:
COC(=O)[C@@]12C(=C)[C@@](C)(C[C@H]3[C@]4(C)CC[C@@H](O)C(C)(C)[C@H]4CC[C@]13C)C(=O)[C@](C)(O)C2=O |r,THB:6:5:10.23.9:25.30.27|
Structure:
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