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Target
Interleukin-1 beta
Ligand
BDBM10355
Substrate
n/a
Meas. Tech.
ChEMBL_776544 (CHEMBL1913641)
IC50
2000±n/a nM
Citation
 Stierle, DB; Stierle, AA; Patacini, B; McIntyre, K; Girtsman, T; Bolstad, E Berkeleyones and related meroterpenes from a deep water acid mine waste fungus that inhibit the production of interleukin 1-ß from induced inflammasomes. J Nat Prod 74:2273-7 (2011) [PubMed]  Article 
Target
Name:
Interleukin-1 beta
Synonyms:
IL1B | IL1B_HUMAN | IL1F2 | Interleukin 1-beta | Interleukin-1 beta | hIL-1beta
Type:
Cytokine
Mol. Mass.:
30734.47
Organism:
Homo sapiens (Human)
Description:
P01584
Residue:
269
Sequence:
MAEVPELASEMMAYYSGNEDDLFFEADGPKQMKCSFQDLDLCPLDGGIQLRISDHHYSKGFRQAASVVVAMDKLRKMLVPCPQTFQENDLSTFFPFIFEEEPIFFDTWDNEAYVHDAPVRSLNCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKEKNLYLSCVLKDDKPTLQLESVDPKNYPKKKMEKRFVFNKIEINNKLEFESAQFPNWYISTSQAENMPVFLGGTKGGQDITDFTMQFVSS
  
Inhibitor
Name:
BDBM10355
Synonyms:
(3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-(4-hydroxyphenyl)propanamido]-3-methylbutanamido]propanamido]-4-oxobutanoic acid | Ac-YVAD-CHO | CHEMBL37630
Type:
Small organic molecule
Emp. Form.:
C23H32N4O8
Mol. Mass.:
492.5222
SMILES:
CC(C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C=O |r|
Structure:
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