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Target
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1
Ligand
BDBM50356012
Substrate
n/a
Meas. Tech.
ChEMBL_775079 (CHEMBL1912274)
IC50
120000±n/a nM
Citation
 Qian, Y; Ahmad, M; Chen, S; Gillespie, P; Le, N; Mennona, F; Mischke, S; So, SS; Wang, H; Burghardt, C; Tannu, S; Conde-Knape, K; Kochan, J; Bolin, D Discovery of 1-arylcarbonyl-6,7-dimethoxyisoquinoline derivatives as glutamine fructose-6-phosphate amidotransferase (GFAT) inhibitors. Bioorg Med Chem Lett 21:6264-9 (2011) [PubMed]  Article 
Target
Name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1
Synonyms:
GFAT | GFPT | GFPT1 | GFPT1_HUMAN | Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 1
Type:
PROTEIN
Mol. Mass.:
78813.10
Organism:
Homo sapiens (Human)
Description:
ChEMBL_775079
Residue:
699
Sequence:
MCGIFAYLNYHVPRTRREILETLIKGLQRLEYRGYDSAGVGFDGGNDKDWEANACKIQLIKKKGKVKALDEEVHKQQDMDLDIEFDVHLGIAHTRWATHGEPSPVNSHPQRSDKNNEFIVIHNGIITNYKDLKKFLESKGYDFESETDTETIAKLVKYMYDNRESQDTSFTTLVERVIQQLEGAFALVFKSVHFPGQAVGTRRGSPLLIGVRSEHKLSTDHIPILYRTARTQIGSKFTRWGSQGERGKDKKGSCNLSRVDSTTCLFPVEEKAVEYYFASDASAVIEHTNRVIFLEDDDVAAVVDGRLSIHRIKRTAGDHPGRAVQTLQMELQQIMKGNFSSFMQKEIFEQPESVVNTMRGRVNFDDYTVNLGGLKDHIKEIQRCRRLILIACGTSYHAGVATRQVLEELTELPVMVELASDFLDRNTPVFRDDVCFFLSQSGETADTLMGLRYCKERGALTVGITNTVGSSISRETDCGVHINAGPEIGVASTKAYTSQFVSLVMFALMMCDDRISMQERRKEIMLGLKRLPDLIKEVLSMDDEIQKLATELYHQKSVLIMGRGYHYATCLEGALKIKEITYMHSEGILAGELKHGPLALVDKLMPVIMIIMRDHTYAKCQNALQQVVARQGRPVVICDKEDTETIKNTKRTIKVPHSVDCLQGILSVIPLQLLAFHLAVLRGYDVDFPRNLAKSVTVE
  
Inhibitor
Name:
BDBM50356012
Synonyms:
AAPTAMINE
Type:
Small organic molecule
Emp. Form.:
C13H12N2O2
Mol. Mass.:
228.2466
SMILES:
COc1cc2ccnc3cc[nH]c(c1OC)c23
Structure:
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