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Target
Small conductance calcium-activated potassium channel protein 2
Ligand
BDBM50356161
Substrate
n/a
Meas. Tech.
ChEMBL_776014 (CHEMBL1913012)
IC50
1600±n/a nM
Citation
 Badarau, E; Dilly, S; Dufour, F; Poncin, S; Seutin, V; Liégeois, JF Synthesis and radioligand binding studies of bis-(8-isopropyl-isoquinolinium) derivatives as ligands for apamin-sensitive sites on cloned SK2 and SK3 channels. Bioorg Med Chem Lett 21:6756-9 (2011) [PubMed]  Article 
Target
Name:
Small conductance calcium-activated potassium channel protein 2
Synonyms:
KCNN2_RAT | Kcnn2 | Small conductance calcium-activated potassium channel | Small conductance calcium-activated potassium channel protein 2 | Small conductance calcium-activated potassium channel protein 2 (KCa2.2)
Type:
Protein
Mol. Mass.:
63876.72
Organism:
Rattus norvegicus (Rat)
Description:
P70604
Residue:
580
Sequence:
MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS
  
Inhibitor
Name:
BDBM50356161
Synonyms:
CHEMBL1909931
Type:
Small organic molecule
Emp. Form.:
C34H38N2
Mol. Mass.:
474.6778
SMILES:
CC(C)c1cccc2cc[n+](C)c(Cc3cccc(Cc4[n+](C)ccc5cccc(C(C)C)c45)c3)c12
Structure:
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