Reaction Details Report a problem with these data
Target
Calcitonin gene-related peptide 1
Ligand
BDBM50356278
Substrate
n/a
Meas. Tech.
ChEMBL_775100 (CHEMBL1912359)
Ki
6800±n/a nM
Citation
 Zartman, CB; Bell, IM; Gallicchio, SN; Graham, SL; Kane, SA; Mallee, JJ; Rutledge, RZ; Salvatore, CA; Vacca, JP; Williams, TM Identification of a novel RAMP-independent CGRP receptor antagonist. Bioorg Med Chem Lett 21:6705-8 (2011) [PubMed]  Article 
Target
Name:
Calcitonin gene-related peptide 1
Synonyms:
CALCA_RAT | CGRP | Calc | Calca | Calcitonin gene-related peptide 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
13950.43
Organism:
RAT
Description:
CGRP 0 RAT::P01256
Residue:
128
Sequence:
MGFLKFSPFLVVSILLLYQACGLQAVPLRSTLESSPGMAATLSEEEARLLLAALVQNYMQMKVRELEQEQEAEGSSVTAQKRSCNTATCVTHRLAGLLSRSGGVVKDNFVPTNVGSEAFGRRRRDLQA
  
Inhibitor
Name:
BDBM50356278
Synonyms:
CHEMBL1910947
Type:
Small organic molecule
Emp. Form.:
C17H16BrF2N3O4S
Mol. Mass.:
476.292
SMILES:
Oc1c(Br)cc(nc1C(=O)NCc1cc(F)cc(F)c1)N1CCCCS1(=O)=O
Structure:
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