Reaction Details Report a problem with these data
Target
Melanin-concentrating hormone receptor 1
Ligand
BDBM50358743
Substrate
n/a
Meas. Tech.
ChEMBL_789586 (CHEMBL1924627)
IC50
4±n/a nM
Citation
 Mihalic, JT; Chen, X; Fan, P; Chen, X; Fu, Y; Liang, L; Reed, M; Tang, L; Chen, JL; Jaen, J; Li, L; Dai, K Discovery of a novel series of melanin-concentrating hormone receptor 1 antagonists for the treatment of obesity. Bioorg Med Chem Lett 21:7001-5 (2011) [PubMed]  Article 
Target
Name:
Melanin-concentrating hormone receptor 1
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
28036.69
Organism:
Macaca fascicularis
Description:
ChEMBL_789586
Residue:
249
Sequence:
INLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQ
  
Inhibitor
Name:
BDBM50358743
Synonyms:
CHEMBL1922270
Type:
Small organic molecule
Emp. Form.:
C25H33F3N2O
Mol. Mass.:
434.5375
SMILES:
C[C@@H]1[C@H]2CN(CCCC3CCOCC3)CC[C@@H]2Cc2[nH]c3ccc(cc3c12)C(F)(F)F |r|
Structure:
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