Reaction Details Report a problem with these data
Target
Prostaglandin E2 receptor EP4 subtype
Ligand
BDBM50359616
Substrate
n/a
Meas. Tech.
ChEMBL_793158 (CHEMBL1931472)
EC50
5.7±n/a nM
Citation
 Hayashi, R; Hosono, Y; Nakatsuji, K; Tanaka, Y; Mori, T; Kanno, T; Makita, K; Moriwaki, M; Ohyama, T; Ochi, Y; Inada, C; Isogaya, M Efficient synthesis of a novel m-phenylene derivative as a selective EP4 agonist inducing follicular growth and maturation in the ovary. Bioorg Med Chem Lett 21:7505-8 (2011) [PubMed]  Article 
Target
Name:
Prostaglandin E2 receptor EP4 subtype
Synonyms:
PE2R4_RABIT | PGE receptor EP4 subtype | PGE2 receptor EP4 subtype | PTGER4 | Prostanoid EP4 receptor
Type:
PROTEIN
Mol. Mass.:
53381.06
Organism:
Oryctolagus cuniculus
Description:
ChEMBL_793158
Residue:
488
Sequence:
MSTPVANASASSMPELLNNPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGGQALCDYSTFILLFFGLSGLSIICAMSIERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGRSRLQFPDTWCFIDWRTNVTAHAAFSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAAAVTSAACRGHPTASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFINQLYQPDLVREISQNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRDRSGQHCSDSRRTSSAMSTHSRSFLSRELKEISSTSQTLLYLPELSENSLAGRNLLPGVPLVGLAQADTTSLRTWRGSETSDSSQGQDSESVLLVDEVGGGGRAGPTPKGSSLQVTFPSETLNLSEKCI
  
Inhibitor
Name:
BDBM50359616
Synonyms:
CHEMBL1928221
Type:
Small organic molecule
Emp. Form.:
C24H32O5
Mol. Mass.:
400.5079
SMILES:
O[C@@H](CC1CCCCC1)\C=C\[C@H]1[C@H](O)C[C@@H]2Oc3c(cccc3CCC(O)=O)[C@H]12 |r|
Structure:
Search PDB for entries with ligand similarity: