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Target
Dihydroorotate dehydrogenase (quinone), mitochondrial
Ligand
BDBM50359691
Substrate
n/a
Meas. Tech.
ChEMBL_792219 (CHEMBL1930746)
IC50
350±n/a nM
Citation
 Erra, M; Moreno, I; Sanahuja, J; Andrés, M; Reinoso, RF; Lozoya, E; Pizcueta, P; Godessart, N; Castro-Palomino, JC Biaryl analogues of teriflunomide as potent DHODH inhibitors. Bioorg Med Chem Lett 21:7268-72 (2011) [PubMed]  Article 
Target
Name:
Dihydroorotate dehydrogenase (quinone), mitochondrial
Synonyms:
DHOdehase | Dhodh | Dihydroorotate Dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial precursor | Dihydroorotate oxidase | PYRD_RAT
Type:
Enzyme
Mol. Mass.:
42672.97
Organism:
Rattus norvegicus (rat)
Description:
The enzyme assay was performed with the histidine-tagged enzyme without cleavage of the tag.
Residue:
395
Sequence:
MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR
  
Inhibitor
Name:
BDBM50359691
Synonyms:
CHEMBL1929435
Type:
Small organic molecule
Emp. Form.:
C20H17FN2O4
Mol. Mass.:
368.3584
SMILES:
CCC(=O)C(C#N)C(=O)Nc1ccc(-c2ccc(F)cc2)c(c1)C(=O)OC
Structure:
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