Reaction Details Report a problem with these data
Target
Perforin-1
Ligand
BDBM50361441
Substrate
n/a
Meas. Tech.
ChEMBL_794525 (CHEMBL1936847)
IC50
15200±n/a nM
Citation
 Spicer, JA; Huttunen, KM; Miller, CK; Denny, WA; Ciccone, A; Browne, KA; Trapani, JA Inhibition of the pore-forming protein perforin by a series of aryl-substituted isobenzofuran-1(3H)-ones. Bioorg Med Chem 20:1319-36 (2012) [PubMed]  Article 
Target
Name:
Perforin-1
Synonyms:
PERF_HUMAN | PFP | PRF1
Type:
PROTEIN
Mol. Mass.:
61392.32
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1285138
Residue:
555
Sequence:
MAARLLLLGILLLLLPLPVPAPCHTAARSECKRSHKFVPGAWLAGEGVDVTSLRRSGSFPVDTQRFLRPDGTCTLCENALQEGTLQRLPLALTNWRAQGSGCQRHVTRAKVSSTEAVARDAARSIRNDWKVGLDVTPKPTSNVHVSVAGSHSQAANFAAQKTHQDQYSFSTDTVECRFYSFHVVHTPPLHPDFKRALGDLPHHFNASTQPAYLRLISNYGTHFIRAVELGGRISALTALRTCELALEGLTDNEVEDCLTVEAQVNIGIHGSISAEAKACEEKKKKHKMTASFHQTYRERHSEVVGGHHTSINDLLFGIQAGPEQYSAWVNSLPGSPGLVDYTLEPLHVLLDSQDPRREALRRALSQYLTDRARWRDCSRPCPPGRQKSPRDPCQCVCHGSAVTTQDCCPRQRGLAQLEVTFIQAWGLWGDWFTATDAYVKLFFGGQELRTSTVWDNNNPIWSVRLDFGDVLLATGGPLRLQVWDQDSGRDDDLLGTCDQAPKSGSHEVRCNLNHGHLKFRYHARCLPHLGGGTCLDYVPQMLLGEPPGNRSGAVW
  
Inhibitor
Name:
BDBM50361441
Synonyms:
CHEMBL1934405
Type:
Small organic molecule
Emp. Form.:
C18H15NO3S
Mol. Mass.:
325.382
SMILES:
O=C1OCc2cc(ccc12)-c1ccc(\C=C2\CCCNC2=O)s1 |w:13.15|
Structure:
Search PDB for entries with ligand similarity: