Reaction Details Report a problem with these data
Target
Tumor susceptibility gene 101 protein
Ligand
BDBM50362891
Substrate
n/a
Meas. Tech.
ChEMBL_800319 (CHEMBL1948069)
IC50
12000±n/a nM
Citation
 Kim, SE; Liu, F; Im, YJ; Stephen, AG; Fivash, MJ; Waheed, AA; Freed, EO; Fisher, RJ; Hurley, JH; Burke, TR Elucidation of New Binding Interactions with the Tumor Susceptibility Gene 101 (Tsg101) Protein Using Modified HIV-1 Gag-p6 Derived Peptide Ligands. ACS Med Chem Lett 2:337-341 (2011) [PubMed]  Article 
Target
Name:
Tumor susceptibility gene 101 protein
Synonyms:
TS101_HUMAN | TSG101
Type:
PROTEIN
Mol. Mass.:
43943.30
Organism:
Homo sapiens (Human)
Description:
ChEMBL_800321
Residue:
390
Sequence:
MAVSESQLKKMVSKYKYRDLTVRETVNVITLYKDLKPVLDSYVFNDGSSRELMNLTGTIPVPYRGNTYNIPICLWLLDTYPYNPPICFVKPTSSMTIKTGKHVDANGKIYLPYLHEWKHPQSDLLGLIQVMIVVFGDEPPVFSRPISASYPPYQATGPPNTSYMPGMPGGISPYPSGYPPNPSGYPGCPYPPGGPYPATTSSQYPSQPPVTTVGPSRDGTISEDTIRASLISAVSDKLRWRMKEEMDRAQAELNALKRTEEDLKKGHQKLEEMVTRLDQEVAEVDKNIELLKKKDEELSSALEKMENQSENNDIDEVIIPTAPLYKQILNLYAEENAIEDTIFYLGEALRRGVIDLDVFLKHVRLLSRKQFQLRALMQKARKTAGLSDLY
  
Inhibitor
Name:
BDBM50362891
Synonyms:
CHEMBL1946260
Type:
Small organic molecule
Emp. Form.:
C59H75N11O22
Mol. Mass.:
1290.2873
SMILES:
C[C@@H](O)[C@H](NC(=O)[C@@H]1C[C@H](CN1C(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCCN1C(C)=O)O\N=C\c1ccc(OC(=O)c2ccc3OCOc3c2)cc1)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(N)=O |r|
Structure:
Search PDB for entries with ligand similarity: