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Target
Low molecular weight protein-tyrosine phosphatase A
Ligand
BDBM50363154
Substrate
n/a
Meas. Tech.
ChEMBL_801146 (CHEMBL1948973)
IC50
214000±n/a nM
Citation
 Chiaradia, LD; Martins, PG; Cordeiro, MN; Guido, RV; Ecco, G; Andricopulo, AD; Yunes, RA; Vernal, J; Nunes, RJ; Terenzi, H Synthesis, biological evaluation, and molecular modeling of chalcone derivatives as potent inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatases (PtpA and PtpB). J Med Chem 55:390-402 (2012) [PubMed]  Article 
Target
Name:
Low molecular weight protein-tyrosine phosphatase A
Synonyms:
PTPA_MYCTU | PTPase | Probable low molecular weight protein-tyrosine-phosphatase | Protein Tyrosine Phosphatase PTPA | mptpA | ptpA
Type:
Hydrolase
Mol. Mass.:
17891.84
Organism:
Mycobacterium tuberculosis
Description:
n/a
Residue:
163
Sequence:
MSDPLHVTFVCTGNICRSPMAEKMFAQQLRHRGLGDAVRVTSAGTGNWHVGSCADERAAGVLRAHGYPTDHRAAQVGTEHLAADLLVALDRNHARLLRQLGVEAARVRMLRSFDPRSGTHALDVEDPYYGDHSDFEEVFAVIESALPGLHDWVDERLARNGPS
  
Inhibitor
Name:
BDBM50363154
Synonyms:
CHEMBL1946993
Type:
Small organic molecule
Emp. Form.:
C21H18O3
Mol. Mass.:
318.3658
SMILES:
COc1cccc(OC)c1\C=C\C(=O)c1ccc2ccccc2c1
Structure:
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