Target
Low molecular weight protein-tyrosine phosphatase A
Ligand
BDBM50363144
Substrate
n/a
Meas. Tech.
ChEMBL_801151 (CHEMBL1948978)
Ki
23000±n/a nM
Citation
 Chiaradia, LDMartins, PGCordeiro, MNGuido, RVEcco, GAndricopulo, ADYunes, RAVernal, JNunes, RJTerenzi, H Synthesis, biological evaluation, and molecular modeling of chalcone derivatives as potent inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatases (PtpA and PtpB). J Med Chem 55:390-402 (2012) [PubMed]  Article 
Target
Name:
Low molecular weight protein-tyrosine phosphatase A
Synonyms:
PTPA_MYCTU | PTPase | Probable low molecular weight protein-tyrosine-phosphatase | Protein Tyrosine Phosphatase PTPA | mptpA | ptpA
Type:
Hydrolase
Mol. Mass.:
17891.84
Organism:
Mycobacterium tuberculosis
Description:
n/a
Residue:
163
Sequence:
MSDPLHVTFVCTGNICRSPMAEKMFAQQLRHRGLGDAVRVTSAGTGNWHVGSCADERAAGVLRAHGYPTDHRAAQVGTEHLAADLLVALDRNHARLLRQLGVEAARVRMLRSFDPRSGTHALDVEDPYYGDHSDFEEVFAVIESALPGLHDWVDERLARNGPS
  
Inhibitor
Name:
BDBM50363144
Synonyms:
CHEMBL1946281
Type:
Small organic molecule
Emp. Form.:
C17H11ClOS
Mol. Mass.:
298.787
SMILES:
Clc1ccc(s1)C(=O)\C=C\c1ccc2ccccc2c1
Structure:
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