Reaction Details Report a problem with these data
Target
Platelet-activating factor acetylhydrolase
Ligand
BDBM50363379
Substrate
n/a
Meas. Tech.
ChEMBL_801435 (CHEMBL1948165)
IC50
20±n/a nM
Citation
 Lin, EC; Hu, Y; Amantea, CM; Pham, LM; Cajica, J; Okerberg, E; Brown, HE; Fraser, A; Du, L; Kohno, Y; Ishiyama, J; Kozarich, JW; Shreder, KR Amides of xanthurenic acid as zinc-dependent inhibitors of Lp-PLA(2). Bioorg Med Chem Lett 22:868-71 (2012) [PubMed]  Article 
Target
Name:
Platelet-activating factor acetylhydrolase
Synonyms:
1-alkyl-2-acetylglycerophosphocholine esterase | 2-acetyl-1-alkylglycerophosphocholine esterase | LDL-PLA(2) | LDL-associated phospholipase A2 | PAF 2-acylhydrolase | PAF acetylhydrolase | PAFAH | PAFA_HUMAN | PLA2G7 | Platelet-activating factor acetylhydrolase
Type:
PROTEIN
Mol. Mass.:
50084.41
Organism:
Homo sapiens (Human)
Description:
ChEMBL_156212
Residue:
441
Sequence:
MVPPKLHVLFCLCGCLAVVYPFDWQYINPVAHMKSSAWVNKIQVLMAAASFGQTKIPRGNGPYSVGCTDLMFDHTNKGTFLRLYYPSQDNDRLDTLWIPNKEYFWGLSKFLGTHWLMGNILRLLFGSMTTPANWNSPLRPGEKYPLVVFSHGLGAFRTLYSAIGIDLASHGFIVAAVEHRDRSASATYYFKDQSAAEIGDKSWLYLRTLKQEEETHIRNEQVRQRAKECSQALSLILDIDHGKPVKNALDLKFDMEQLKDSIDREKIAVIGHSFGGATVIQTLSEDQRFRCGIALDAWMFPLGDEVYSRIPQPLFFINSEYFQYPANIIKMKKCYSPDKERKMITIRGSVHQNFADFTFATGKIIGHMLKLKGDIDSNVAIDLSNKASLAFLQKHLGLHKDFDQWDCLIEGDDENLIPGTNINTTNQHIMLQNSSGIEKYN
  
Inhibitor
Name:
BDBM50363379
Synonyms:
CHEMBL1945882
Type:
Small organic molecule
Emp. Form.:
C16H12N2O3
Mol. Mass.:
280.2781
SMILES:
Oc1cccc2c(O)cc(nc12)C(=O)Nc1ccccc1
Structure:
Search PDB for entries with ligand similarity: