Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 2
Ligand
BDBM50363425
Substrate
n/a
Meas. Tech.
ChEMBL_800169 (CHEMBL1947643)
IC50
34±n/a nM
Citation
 Yang, MG; Xiao, Z; Shi, Q; Cherney, RJ; Tebben, AJ; De Lucca, GV; Santella, JB; Mo, R; Cvijic, ME; Zhao, Q; Barrish, JC; Carter, PH Synthesis of 3-phenylsulfonylmethyl cyclohexylaminobenzamide-derived antagonists of CC chemokine receptor 2 (CCR2). Bioorg Med Chem Lett 22:1384-7 (2012) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 2
Synonyms:
C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1)
Type:
Enzyme
Mol. Mass.:
41932.32
Organism:
Human
Description:
P41597
Residue:
374
Sequence:
MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGNMLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTKCQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHRAVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCINPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSIGRAPEASLQDKEGA
  
Inhibitor
Name:
BDBM50363425
Synonyms:
CHEMBL1947044
Type:
Small organic molecule
Emp. Form.:
C27H32F3N3O4S
Mol. Mass.:
551.621
SMILES:
FC(F)(F)c1cccc(c1)C(=O)NCC(=O)N[C@H]1CC[C@@H](NC2CCC2)[C@@H](CS(=O)(=O)c2ccccc2)C1 |r|
Structure:
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