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Target
Carbonic anhydrase
Ligand
BDBM10887
Substrate
n/a
Meas. Tech.
ChEMBL_801827 (CHEMBL1947439)
Ki
38±n/a nM
Citation
 Ohradanova, A; Vullo, D; Pastorekova, S; Pastorek, J; Jackson, DJ; Wörheide, G; Supuran, CT Cloning, characterization and sulfonamide inhibition studies of ana-carbonic anhydrase from the living fossil sponge Astrosclera willeyana. Bioorg Med Chem 20:1403-10 (2012) [PubMed]  Article 
Target
Name:
Carbonic anhydrase
Synonyms:
Astrosclerin-3
Type:
PROTEIN
Mol. Mass.:
33233.07
Organism:
Astrosclera willeyana
Description:
ChEMBL_801827
Residue:
292
Sequence:
MMAYKVLHFVVISLGLVTLVASRCDFNYYNQRAWLSCPGSQCGGNRQSPINIDTEKTKANNSLIALRFNDYDDPVDGDFENLGTTVEFVPETKDATLTNHLGTYDLLQFHFHWGRDSSEGSEHRIDDEQYSAEIHFVHLKQGASPSDTAGDTFSVVAVLCEAADIPIRGVWAKLSPVPTGHEDSHSVSDLVYTDLLPRNRDYYHYEGSLTTPLCDETVQWFVLKNTIKIPKAFLTMLRRVESDEDGTLLTFNFRNLQRLNGRQVFEFPPDVDNGEDKKRKRRNNRHGRDHHG
  
Inhibitor
Name:
BDBM10887
Synonyms:
Sulfamate 7 | Topiramate (TPM) | US11535599, Example topiramate | [(1R,2S,6S,9R)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.0^{2,6}]dodecan-6-yl]methyl sulfamate
Type:
Small organic molecule
Emp. Form.:
C12H21NO8S
Mol. Mass.:
339.362
SMILES:
CC1(C)O[C@@H]2CO[C@@]3(COS(N)(=O)=O)OC(C)(C)O[C@H]3[C@@H]2O1 |r|
Structure:
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