Reaction Details Report a problem with these data
Target
TGF-beta receptor type-1
Ligand
BDBM50365545
Substrate
n/a
Meas. Tech.
ChEMBL_808007 (CHEMBL1961066)
IC50
170±n/a nM
Citation
 Amada, H; Sekiguchi, Y; Ono, N; Matsunaga, Y; Koami, T; Asanuma, H; Shiozawa, F; Endo, M; Ikeda, A; Aoki, M; Fujimoto, N; Wada, R; Sato, M Design, synthesis, and evaluation of novel 4-thiazolylimidazoles as inhibitors of transforming growth factor-ß type I receptor kinase. Bioorg Med Chem Lett 22:2024-9 (2012) [PubMed]  Article 
Target
Name:
TGF-beta receptor type-1
Synonyms:
ALK-5 | ALK5 | Activin A receptor type II-like protein kinase of 53kD | Activin receptor-like kinase 5 | SKR4 | Serine/threonine-protein kinase receptor R4 | TGF-beta receptor type I | TGF-beta type I receptor | TGFBR1 | TGFR-1 | TGFR1_HUMAN | TbetaR-I | Transforming growth factor-beta receptor type I
Type:
enzyme
Mol. Mass.:
55968.24
Organism:
Homo sapiens (Human)
Description:
P36897
Residue:
503
Sequence:
MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
  
Inhibitor
Name:
BDBM50365545
Synonyms:
CHEMBL1955884
Type:
Small organic molecule
Emp. Form.:
C25H24N4O3S
Mol. Mass.:
460.548
SMILES:
Cc1csc(n1)-c1[nH]c(CCCCC(=O)Nc2ccccc2)nc1-c1ccc2OCOc2c1
Structure:
Search PDB for entries with ligand similarity: