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Target
Renin
Ligand
BDBM50365571
Substrate
n/a
Meas. Tech.
ChEMBL_808016 (CHEMBL1961075)
IC50
0.08±n/a nM
Citation
 Lacombe, P; Arbour, M; Aspiotis, R; Cauchon, E; Chen, A; Dubé, D; Falgueyret, JP; Fournier, PA; Gallant, M; Grimm, E; Han, Y; Juteau, H; Liu, S; Mellon, C; Ramtohul, Y; Simard, D; St-Jacques, R; Tsui, GC 3,4-Diarylpiperidines as potent renin inhibitors. Bioorg Med Chem Lett 22:1953-7 (2012) [PubMed]  Article 
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
  
Inhibitor
Name:
BDBM50365571
Synonyms:
CHEMBL1957789
Type:
Small organic molecule
Emp. Form.:
C33H40F2N2O4
Mol. Mass.:
566.6785
SMILES:
COCC(F)(F)COCc1ccc(cc1)[C@@]1(O)CCNC[C@@H]1c1ccc(cc1C)-c1ccccc1CCNC(C)=O |r|
Structure:
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