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Target
D(1A) dopamine receptor
Ligand
BDBM50279866
Substrate
n/a
Meas. Tech.
ChEBML_58170
IC50
>15000±n/a nM
Citation
 Jaen, JC; Caprathe, BW; Wise, LD; Smith, SJ; Pugsley, TA; Heffner, TG; Meltzer, LT Novel 4,5,6,7-tetrahydrobenzothiazole dopamine agonists display very low stereoselectivity in their interaction with dopamine receptors. Bioorg Med Chem Lett 1:189-192 (1991)    Article 
Target
Name:
D(1A) dopamine receptor
Synonyms:
DOPAMINE D1 | DRD1_RAT | Dopamine D1 high | Dopamine D1 low | Dopamine receptor | Dopamine receptor D1 | Dopamine1-like | Drd1 | Drd1a
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49429.75
Organism:
RAT
Description:
P18901
Residue:
446
Sequence:
MAPNTSTMDEAGLPAERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPLGPFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFQYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTWPLDGNFTSLEDTEDDNCDTRLSRTYAISSSLISFYIPVAIMIVTYTSIYRIAQKQIRRISALERAAVHAKNCQTTAGNGNPVECAQSESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFISNCMVPFCGSEETQPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFQKAFSTLLGCYRLCPTTNNAIETVSINNNGAVVFSSHHEPRGSISKDCNLVYLIPHAVGSSEDLKKEEAGGIAKPLEKLSPALSVILDYDTDVSLEKIQPVTHSGQHST
  
Inhibitor
Name:
BDBM50279866
Synonyms:
(R)-6-(4-Pyridin-2-yl-piperazin-1-yl)-4,5,6,7-tetrahydro-benzothiazol-2-ylamine | CHEMBL58265
Type:
Small organic molecule
Emp. Form.:
C16H21N5S
Mol. Mass.:
315.436
SMILES:
Nc1nc2CC[C@H](Cc2s1)N1CCN(CC1)c1ccccn1
Structure:
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