Reaction Details Report a problem with these data
Target
D(2) dopamine receptor
Ligand
BDBM50279867
Substrate
n/a
Meas. Tech.
ChEMBL_58542 (CHEMBL667478)
IC50
280±n/a nM
Citation
 Jaen, JC; Caprathe, BW; Wise, LD; Smith, SJ; Pugsley, TA; Heffner, TG; Meltzer, LT Novel 4,5,6,7-tetrahydrobenzothiazole dopamine agonists display very low stereoselectivity in their interaction with dopamine receptors. Bioorg Med Chem Lett 1:189-192 (1991)    Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2_RAT | Dopamine D2 receptor | Dopamine2-like | Drd2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
50931.60
Organism:
Rattus norvegicus (rat)
Description:
P61169
Residue:
444
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
  
Inhibitor
Name:
BDBM50279867
Synonyms:
(S)-6-(4-Pyridin-2-yl-piperazin-1-yl)-4,5,6,7-tetrahydro-benzothiazol-2-ylamine | CHEMBL56584
Type:
Small organic molecule
Emp. Form.:
C16H21N5S
Mol. Mass.:
315.436
SMILES:
Nc1nc2CC[C@@H](Cc2s1)N1CCN(CC1)c1ccccn1
Structure:
Search PDB for entries with ligand similarity: